Department of Anesthesiology, Pain Management, and Intensive Care, Udayana University, Sanglah General Hospital Bali.
* Corresponding Author
GSC Biological and Pharmaceutical Sciences, 2026, 36(03), 122–128
Article DOI: 10.30574/gscbps.2026.36.3.0316
Received on 02 August 2026; revised on 10 September 2026; accepted on 13 September 2026
Background: Postoperative pain after mastectomy often decreases patients' quality of life and requires effective pain management. The RISS block (Rhomboid Intercostal and Sub-Serratus) is an alternative technique that can reduce pain and opioid requirements after surgery.
Methods: This study is a single-blind randomized clinical trial involving 40 mastectomy patients, divided into two groups: one group received general anesthesia with the RISS block, and the other group received only general anesthesia. Primary outcomes measured included opioid consumption in the first 24 hours postoperatively, pain intensity using the NRS scale, and the time to first use of PCA analgesics.
Results: The group receiving the RISS block showed a significant reduction in opioid consumption (20 ± 20 mcg vs. 100 ± 40 mcg, p < 0.05), lower pain intensity at hours 1, 3, 6, 12, and 24 (p < 0.05), and a longer time to first use of PCA (8 ± 18 hours vs. 3 ± 2 hours, p < 0.05).
Conclusion: The RISS block is effective in reducing opioid requirements and controlling postoperative pain after mastectomy. This technique can be a safe and efficient option in postoperative pain management.
RISS, Mastectomy, Analgesia, Regional Anesthesia, Pain management
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Nyoman Damar Widya Dharma, Putu Pramana Suarjaya, Kadek Agus Heryana Putra, I Made Gede Widnyana and Tjokorda Gde Agung Senapathi. EFFECTIVENESS OF RHOMBOID INTERCOSTAL AND SUB-SERRATUS (RISS) PLANE BLOCK REGIONAL ANESTHESIA AS ADJUVANT ANALGESIA IN MANAGEMENT OF POST-OPERATIVE PAIN IN PATIENTS UNDERGOING MASTECTOMY SURGERY. GSC Biological and Pharmaceutical Sciences, 2026, 36(03), 122–128. Article DOI: https://doi.org/10.30574/gscbps.2026.36.3.0316.