1 Department of Plant Biopolymers and Chemical Modification of Natural Compounds, Tbilisi State Medical University, I. Kutateladze Institute of Pharmacochemistry, Tbilisi 0159, Georgia.
2 LASEVE Laboratory, Fundamental Sciences Department, Quebec University at Chicoutimi, Chicoutimi, QC, Canada.
3 Department of Preclinical Pharmacological Research, Tbilisi State Medical University, I. Kutateladze Institute of Pharmacochemistry, Tbilisi 0159, Georgia.
4 Department of Phytochemical Research, Tbilisi State Medical University, I. Kutateladze Institute of Pharmacochemistry, Tbilisi 0159, Georgia.
* Corresponding Author
ORCID Details
Nanuli Nadaraia: https://orcid.org/0000-0002-1228-9556
Nana Barbakadze: https://orcid.org/0000-0001-8051-0606
Jean Legault: https://orcid.org/0000-0001-6292-6798
Karen Mulkijanyan: https://orcid.org/0000-0001-9360-3422
Vaktang Mshvildadze: https://orcid.org/0000-0002-4239-4832
GSC Biological and Pharmaceutical Sciences, 2026, 37(02), 030–035
Article DOI: 10.30574/gscbps.2026.37.2.0371
Received on 16 September 2026; revised on 28 October 2026; accepted on 30 October 2026
In order to search for new biologically active steroids from pregn-16-en-3β-ol-20-one, some isomeric derivatives of 5α-androstanopyrazolines were synthesized and their cytotoxic, anti-inflammatory activity was studied. The structures of the synthesized compounds are proven by NMR data of 1H, 13C and mass spectra.
Synthesis, Steroidal Pyrazolines, Cytotoxic and Anti-Inflammatory Activity
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Nanuli Nadaraia, Nana Barbakadze, Meri Kakhabrishvili, Jean Legault, Karen Mulkijanyan and Vakhtang Mshvildadze. MODIFICATION OF PREGNENOLONE INTO 5A-ANDROSTANO [17,16-D] PYRAZOLINES: BIOACTIVITY INSIGHT. GSC Biological and Pharmaceutical Sciences, 2026, 37(02), 030–035. Article DOI: https://doi.org/10.30574/gscbps.2026.37.2.0371.