Proteins in the kinetochore generate forces to drive chromosomes movement

To accomplish the precise segregation of chromosomes, the kinetochore must be form incentive interaction with motor proteins. Any error happens in chromosome segregation led to aneuploidy that consider as main factor to cause the cancers and many birth defects. Kinetochore is a proteinous complex structure consist of a hundred of proteins. It’s performed many functions such as it connects movement of chromosomes to microtubule, it acts as observer for chromosomes biorentation, beside the main role in chromosomes segregation. In this review we described the proteins content of kinetochore and the important role of these proteins in generating forces to drive the movement of chromosomes, also we clarified some experiments that used to identify these proteins and support their functions.